Plenary paper Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival
نویسندگان
چکیده
Adrian Wiestner,1,2 Mahsa Tehrani,2 Michael Chiorazzi,1 George Wright,1 Federica Gibellini,2 Kazutaka Nakayama,2 Hui Liu,2 Andreas Rosenwald,3 H. Konrad Muller-Hermelink,3 German Ott,3 Wing C. Chan,4 Timothy C. Greiner,4 Dennis D. Weisenburger,4 Julie Vose,4 James O. Armitage,4 Randy D. Gascoyne,5 Joseph M. Connors,5 Elias Campo,6 Emilio Montserrat,6 Francesc Bosch,6 Erlend B. Smeland,7 Stein Kvaloy,7 Harald Holte,7 Jan Delabie,7 Richard I. Fisher,8 Thomas M. Grogan,8 Thomas P. Miller,8 Wyndham H. Wilson,1 Elaine S. Jaffe,1 and Louis M. Staudt,1 for the Lymphoma/Leukemia Molecular Profiling Project
منابع مشابه
Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival.
A gene expression signature of tumor proliferation rate in mantle cell lymphoma (MCL) is an overriding molecular predictor of the length of survival following diagnosis. Many strongly proliferative MCL tumors have exceptionally high cyclin D1 mRNA levels and preferentially express short cyclin D1 mRNA isoforms. We demonstrate here that these short mRNAs are cyclin D1a isoforms with truncated 3'...
متن کاملPoint mutations and genomic deletions in Cyclin D1 create stable truncated mRNAs that are associated with increased proliferation rate and shorter survival in mantle cell lymphoma
Word Count: 199 Main Text Word Count: 4996
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Background & Objective: Glioblastoma-multiforme is the high grade form of astrocytic tumors with a short survival time, which are the most common type of brain tumors. Therefore, finding new therapeutic options is essential. Cyclin D1 is expressed in some human malignancies and can be a potential target for therapeutic intervention. The aim of the present study was to determine...
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